TECHNOLOGY
Application of Freeze-drying manufacturing method in cosmetics
The stability of human stem cell culture solutions and growth factors deteriorates over time, which causes the gradual loss of efficacy. We have applied a special treatment using freeze-drying technology on beauty lotions, serums, and emulsions with beauty components compounded, which are then thawed again to make the product (two-component cosmetics for preparation before use). This manufacturing method is characterized by the retention of the original form, minimizing changes in color and taste. In addition, there are many advantages such as the residual fine gaps in the areas of crystallized ice which allows the added water to permeate, resulting in high recovery and reproducibility when returned to liquid form. However, the application of this technology in cosmetics was delayed because of the difficulty in clarifying the temperature range and period for efficient freezing. We have utilized our expert technology and experience in enabling freeze-drying of cosmetics.
Absolutely no preservatives added
Our unique freeze-drying technology allows not only the non-addition of preservatives but the absolute non-addition of preservatives. Since these products come directly in contact with your delicate skin, experienced personnel conduct many of the processes manually. The manufacturing process is carried out carefully with hygiene measures enforced for the air conditioning on the premises and the devices used for manufacture.
Improved permeation efficiency
Strong permeation capacity through the epidermis (keratin layer) allows delivery of the active ingredients underneath the epidermis.
Decreased skin stimulation
Encapsulation of active ingredients with skin irritability (such as retinol) allows the stimulation to be reduced dramatically.
Improved active ingredient stability
Prevents the degradation of active ingredients on the skin and in the body and retains optimal concentration over prolonged period, allowing the effect to be sustained for a long period of time.
More than 22,000 types of marine microorganisms
The sea is the source of the earth’s energy. It is said that 95% of the sea is yet to be explored. While there are more than 22,000 types of marine microorganisms discovered up to present, many more marine microorganisms with the potential for use in cosmetics are being discovered each year. The Malaspina expedition, who received approval from Carlos the Third as king at the time, conducted exploration of marine organisms from July 30, 1789, to September 21, 1794. In recent years, exploration of marine organisms have been conducted by research vessel Hespérides from December 2010 to July 2011.
Three challenges that made liposome capsules unsuitable for cosmetics
In order to overcome these three challenges, we use low-molecular collagen as the constituent and adopted the micro-fluid manufacturing method to create the nano-liposome capsules. Various growth factors and active substances such as SOD found in stem cell culture fluid are in the form of polypeptides, which involve binding of the tens to hundreds of amino acids in a similar manner to thread tangles. These are aggregated to protein in yarn-ball form (high molecular collagen), which is then surrounded by low molecular collage and ceramide polymers by the micro-fluid manufacturing method to create the liposome structure. As a result, the issues of fragility and degeneration of amino acid components were resolved, and liposome capsules were found to retain the effect for 2 and 3 years within the cosmetic product.
Difficulty in compounding in products while maintaining the capsule structure
Difficulty in enveloping water-soluble active ingredients in the capsules
Existing liposome components cause degeneration of amino acids.
